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目的：探讨慢传输型便秘（ＳＴＣ）结肠壁内神经肽的变化。方法：对１４例ＳＴＣ和１１例非梗阻性直肠腺癌患者的乙状结肠标本进行了免疫组化研究；用半定量法分析其结果。结果：ＳＴＣ患者乙状结肠肌间神经丛内血管活性肠肽（ＶＩＰ）和Ｐ物质（ＳＰ）含量明显降低（Ｐ＜０．０１），而粘膜层内无明显变化。结论：ＳＴＣ患者结肠传输缓慢与其结肠壁肌间神经丛内ＶＩＰ和ＳＰ能神经元数量减少或功能障碍有关。
Objective: To investigate the changes of neuropeptides in the colon wall of slow transit constipation (STC). Methods: The sigmoid colon specimens from 14 patients with STC and 11 patients with non-obstructive rectal adenocarcinoma were studied by immunohistochemistry and the results were analyzed by semi-quantitative analysis. Results: The content of vasoactive intestinal peptide (VIP) and substance P (SP) in the sigmoid colon myenteric plexus in STC patients was significantly lower than that in STC patients (P <0.01). CONCLUSIONS: The slow transit of colon in STC patients is associated with a decrease in the number of VIP and SP can neurons in the colon wall myenteric plexus or dysfunction.