为探讨细胞间粘附分子－ １（ＩＣＡＭ－ １） 在原发性肝细胞癌的表达状况及其在肝癌发生中的作用，利用免疫组织化学技术链菌素亲生物蛋白（ＬＳＡＢ） 法检测３０ 例乙型肝炎后肝细胞癌及癌旁肝组织ＩＣＡＭ－ １ 的表达情况。结果　肝癌组织中，ＩＣＡＭ－ １ 存在一定程度的表达，其中癌组织阳性率为４３ ．３％ ，多为弱表达；癌旁肝组织明显高于癌组织，阳性率为７８ ．６ ％ ，多呈弥漫强阳性表达，二者差异有显著性（ Ｐ＜ ０ ．０１） 。结论　ＩＣＡＭ－ １ 与肝癌的发生有一定的关系，ＩＣＡＭ－ １缺乏或弱表达可能是原发性肝细胞癌发生过程中的重要免疫逃逸机制之一。 To investigate the expression of intercellular adhesion molecule-1 (ICAM-1) in primary hepatocellular carcinoma and its role in hepatocarcinogenesis, immunohistochemical technique streptavidin probiotic protein (LSAB) was used to detect 30 The expression of ICAM-1 in hepatocellular carcinoma and adjacent liver tissue after hepatitis B. Results There was a certain degree of expression of ICAM-1 in hepatocellular carcinoma. The positive rate of cancer tissue was 43. 3%, mostly weak expression; cancer adjacent liver tissue was significantly higher than cancer, positive rate was 78. 6%, mostly diffuse strong positive expression, the difference was significant (P < 0.01). Conclusion ICAM-1 has a certain relationship with the occurrence of hepatocellular carcinoma. The lack or weak expression of ICAM-1 may be one of the important immune escape mechanisms in the development of primary hepatocellular carcinoma.