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目的:探讨加替沙星不良反应特点,为临床合理用药提供参考。方法:采用回顾性分析方法对1999年～2006年国内外文献所检索到的加替沙星不良反应1406病例报告进行统计、分析。结果:加替沙星所致不良反应累及多个系统-器官,其中皮肤及其附件损害最多,占26.97%,其次为消化系统损害,占22.12%。血糖异常占12.45%,全身性损伤占9.25%,神经系统损伤占9.10%,心血管系统损害占7.11%以及其他器官组织损害占5.12%。结论:加替沙星所致不良反应可累及全身各个系统,应警惕加替沙星的不良反应。
Objective: To investigate the characteristics of adverse reactions of gatifloxacin and provide reference for clinical rational drug use. Methods: A retrospective analysis was performed on 1406 cases of gatifloxacin-related adverse reactions retrieved from domestic and foreign literature from 1999 to 2006. Results: Adverse reactions caused by gatifloxacin involved multiple systems - organs, with the most damage to skin and its appendages, accounting for 26.97%, followed by digestive system damage, accounting for 22.12%. Blood glucose abnormalities accounted for 12.45%, systemic injuries accounted for 9.25%, nervous system damage accounted for 9.10%, cardiovascular system damage accounted for 7.11% and other organ damage accounted for 5.12%. CONCLUSIONS: Gatifloxacin-induced adverse reactions can affect all systems of the body and precautions should be taken with regard to the adverse effects of gatifloxacin.