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树突状细胞(DC)是目前已知功能最强的抗原呈递细胞。它既可以激活初始免疫应答,又能够抑制免疫反应,这与其表达的多种模式识别受体有关,其中DC-SIGN是C型凝集素受体的主要成员,由于它在DC的细胞粘附、迁移、激活初始T细胞、引发免疫反应及参与病原体免疫逃逸等多个方面发挥免疫调节作用,已经成为近年来的研究热点,对其功能的研究可能会为某些疾病提供新的治疗方法,具有重要的临床意义。本文就DC-SIGN免疫调节机制的最新进展做一综述。
Dendritic cells (DCs) are currently the most potent antigen presenting cells. It can activate the initial immune response, but also can inhibit the immune response, which is related to its expression of a variety of pattern recognition receptors, of which DC-SIGN is a major member of the C-type lectin receptor, due to its cell adhesion in DC, It has become a hot research topic in recent years to study the function of immune system in many aspects such as migration, activation of naive T cells, initiation of immune response and involvement in immune escape of pathogens. The study of its function may provide new treatments for some diseases, Important clinical significance. This review summarizes the latest progress of DC-SIGN immune regulation mechanism.