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ATF3转录激活因子3是转录因子ATF/CREB家族中成员之一,为一适应性反应基因参与细胞内外复杂进程。大量研究表明,其通过精细调控增殖及凋亡间平衡在肿瘤的形成和侵袭转移方面发挥重要作用,然而这种作用依赖靶基因和细胞内外环境的不同表现为双重作用,或抑制肿瘤形成或促进肿瘤发生。现就ATF3在肿瘤方面的研究进展予以综述。
ATF3 transcriptional activator 3 is a member of transcription factor ATF / CREB family, which is an adaptive response gene involved in the complex processes inside and outside the cell. Numerous studies have shown that it plays an important role in the formation and invasion and metastasis of tumor by finely regulating the balance between proliferation and apoptosis. However, this effect depends on the dual performance of the target gene and the intracellular and extracellular environment, or the inhibition of tumor formation or promotion Tumorigenesis. The progress of ATF3 in oncology is reviewed.