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本文收集了1980~1990年滋养细胞肿瘤180例,其中侵饰性葡萄胎(恶葡)118例,绒毛膜癌(绒癌)62例。治疗方法:采用化疗为主的综合治疗方案,首选药物为5-氟脲嘧啶(5-FU)和更生霉素(KSM),8天或5天为一疗程,间隔时间分别为3周或2周。结果:恶葡的生存率为98.3%;绒癌的生存率为85.4%;总的死亡率为14.52%。结论:5天一疗程的化疗效果相似于8天的疗程效果,而且化疗副反应轻,周期间隔短,病人易于接受,故临床应推广;同时对于某些病例尚须手术治疗。
This article collected from 1980 to 1990, 180 cases of trophoblastic tumors, including invasive mole (118), choriocarcinoma (choriocarcinoma) in 62 cases. Treatment: chemotherapy-based comprehensive treatment program, the preferred drug for the 5-fluorouracil (5-FU) and dactinomycin (KSM), 8 days or 5 days for a course of treatment, the interval was 3 weeks or 2 week. Results: The survival rate of the malignant tumor was 98.3%; the survival rate of the choriocarcinoma was 85.4%; the total mortality rate was 14.52%. CONCLUSION: The 5-day course of chemotherapy is similar to that of 8-day course of treatment. In addition, the side effects of chemotherapy are light, the intervals are short and the patients are easy to accept. Therefore, it should be popularized clinically. In some cases, surgical treatment is still required.