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目的探讨高血压病及其血管并发症患者血浆同型半胱氨酸(Hcy)检测的临床意义。方法选取116例高血压病患者,其中单纯高血压病48例,合并冠心病37例,合并糖尿病31例,并随即抽取同期健康者38例作为对照组,采用循环酶法检测Hcy水平。结果高血压病患者血浆Hcy水平[(17.23±3.30)μmol/L)]高于对照组[(9.68±2.52)μmol/L],差异有统计学意义(P<0.05);同时高血压病合并冠心病、糖尿病患者血浆Hcy水平[(19.86±4.62)μmol/L,(21.15±4.28)μmol/L]与对照组比较均明显升高(P<0.05)。结论高血压病患者Hcy水平增高可能在血管性疾病的发生发展中起着一定的作用,是心脑血管疾病的一个独立危险因子。
Objective To investigate the clinical significance of detecting plasma homocysteine (Hcy) in patients with hypertension and its vascular complications. Methods A total of 116 hypertensive patients were selected, including 48 cases of simple hypertension, 37 cases of coronary heart disease and 31 cases of diabetes mellitus. Thirty-eight healthy subjects were selected as the control group, and the level of Hcy was detected by circulating enzyme. Results The plasma Hcy level was significantly higher in hypertensive patients (17.23 ± 3.30 μmol / L) than that in the control group (9.68 ± 2.52 μmol / L, P <0.05) Plasma homocysteine levels in patients with coronary heart disease and diabetes [(19.86 ± 4.62) μmol / L, (21.15 ± 4.28) μmol / L] were significantly higher than those in the control group (P <0.05). Conclusion Hcy in hypertensive patients may play an important role in the development of vascular diseases and is an independent risk factor for cardiovascular and cerebrovascular diseases.