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食用多酚类,包括黄酮类化合物,对癌症具有预防作用,其机制为抑制细胞色素P450(CYP)的转录和活化。通过乙氧基吩(口恶)嗪酮去乙基作用(EROD)实验、bDNA扩增技术研究了不同的甲氧基化黄酮(MF)化合物(共选用19个此类化合物)对细胞色素CYP1B1 mRNA表达的抑制作用。
The consumption of polyphenols, including flavonoids, has a preventive effect on cancer by inhibiting the transcription and activation of cytochrome P450 (CYP). Different methoxylated flavonoids (MF) compounds (a total of 19 of these compounds) were tested against cytochrome CYP1B1 by ethoxyphene-demethylation (EROD) and bDNA amplification techniques. Inhibition of mRNA expression.