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目的 观察胆道疾病患者血清可溶性白细胞介素2受体 (sIL-2R)的变化 ,以了解其免疫功能。方法采用ELISA法检测了33例胆道疾病患者的血清sIL-2R。 结果 胆道疾病无黄疸组 (n=10)、良性梗阻性黄疸组(n=10)和恶性梗阻性黄疸组 (n=13)的血清sIL-2R水平均明显高于对照组 (P<0.05或0.01) ;无黄疸组、良性梗阻性黄疸组和恶性梗阻性黄疸组的sIL-2R水平依次递增 ,各组间有显著性差异 (均P<0.01) ;胆道疾病各组术后2周血清sIL -2R水平均明显下降 (均P<0.01) ;sIL-2R与血清总胆红素和丙氨酸转氨酶呈显著正相关 (均P<0.01)。结论 胆道疾病患者血清sIL-2R水平升高 ,免疫功能受抑制。
Objective To observe the changes of serum soluble interleukin-2 receptor (sIL-2R) in patients with biliary tract diseases to understand its immune function. Methods Serum sIL-2R was detected in 33 patients with biliary disease by ELISA. Results Serum sIL-2R levels in patients with biliary tract disease without jaundice (n = 10), benign obstructive jaundice (n = 10) and malignant obstructive jaundice (n = 13) were significantly higher than those in the control group 0.01). The levels of sIL-2R in non-jaundice group, benign obstructive jaundice group and malignant obstructive jaundice group increased successively with significant difference (all P <0.01). Serum sIL -2R levels were significantly decreased (all P <0.01); sIL-2R and serum total bilirubin and alanine aminotransferase was significantly correlated (P <0.01). Conclusion Serum sIL-2R level is elevated in patients with biliary tract diseases, and immune function is inhibited.