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目的探讨米非司酮和米索前列醇抗早孕出血的有效治疗方法。方法对双米药流胚胎排出当天出血超过月经来潮的第1天出血量者166例进行随机分组治疗 ,A组42例 ,口服乙烯雌酚0 5mg ,1天1次 ,连服6天 ;B组41例行彻底刮宫术 ,其中10例组织送病检 ;C组41例 ,在刮宫同时口服乙烯雌酚0 5mg ,1天1次 ,连服6天 ;D组42例进行对照观察。结果A组出血减少 ,以缩短持续时间为主(P<0 05) ,B组出血减少 ,以减少出血量为主(P<0 05) ,C组在出血量及出血时间上均减少(P<0 01) ,诊刮病理为少量绒毛组织。结论双米抗早孕出血的原因是绒毛残留 ,雌孕激素失衡延长出血时间。彻底诊刮及雌激素替代可减少出血。
Objective To investigate the effective treatment of mifepristone and misoprostol in preventing early pregnancy bleeding. Methods A total of 166 patients in group A received 42 mg of diethylstilbestrol orally with 0.5 mg of diethylstilbestrol once a day for 6 days. Group B 41 cases of complete curettage, of which 10 cases were sent for pathological examination; C group of 41 cases, while taking diethylstilbestrol 0 5mg curettage, 1 day 1, and even for 6 days; D group 42 cases were observed. Results The bleeding in group A was decreased, the duration of bleeding was the main factor (P <0.05), the bleeding in group B was decreased to reduce the amount of bleeding (P <0.05), and the amount of bleeding and bleeding in group C <0 01), curettage pathology of a small amount of villous tissue. Conclusion The reason of double resistance to early pregnancy bleeding is residual villus, estrogen and progesterone imbalance prolong the bleeding time. Complete curettage and estrogen replacement can reduce bleeding.