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患者男,59岁,发现左大腿皮肤肿物7个月就诊,肿物活检送病理检查,镜下病理学表现为:瘤细胞呈圆形或类圆形,胞质丰富,胞核大小不一,核仁明显,核分裂象可见,免疫组化结果:CD3(+),CD30(弥漫+),LCA(+),Ki-67(约60%+),CD5(灶+),Bcl-2(+/-),CD45RO(+),Vimentin(+),CD56,CD20,CD23,CD4,CD8,CD79a,CD38,CD15,CD68,Cyclin D1,SMA,S-100,CK和TIA-1均(-),其中,LCA(+)提示淋巴造血系统肿瘤;CD20,CD23和CD79a(-)除外B细胞来源肿瘤;CD3和CD45RO(+)提示T细胞来源肿瘤;CD30(弥漫+)提示间变性大T细胞淋巴瘤。结合免疫组化结果,诊断为原发皮肤间变性大T细胞淋巴瘤。
Male, 59 years old, found the left thigh skin tumor 7 months treatment, biopsy sent to pathological examination, microscopic pathology showed: tumor cells were round or round, rich in cytoplasm, the size of the nucleus , Obvious nucleoli, mitotic figures can be seen, immunohistochemistry results: CD3 (+), CD30 (diffuse +), LCA (+), Ki-67 (about 60% +), CD5 (-), Vimentin (+), CD56, CD20, CD23, CD4, CD8, CD79a, CD38, CD15, CD68, Cyclin D1, SMA, S-100, CK and TIA- ), In which LCA (+) suggests lymphoid hematopoietic tumors; CD20, CD23 and CD79a (-) except for B cell-derived tumors; CD3 and CD45RO (+) suggest T-cell derived tumors; Cell lymphoma. Combined with the results of immunohistochemistry, the diagnosis of primary cutaneous anaplastic large T cell lymphoma.