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日本农林水产研究所利用遗传基因重组技术成功地开发出可降低害虫耐寒能力的微生物农药，并收到明显的效果。 很多冬眠害虫为避免在严冬中冻死，在冬季来临之前便开始在体内积聚糖分，并使体内的水温降到可结冰的温度。此外，肠内残留的食物也随着体内水分温度的下降而形成
Japan Institute of Agriculture, Forestry and Fisheries using genetic recombination technology successfully developed to reduce pest cold hardiness microbial pesticides, and received significant results. Many hibernating pests To avoid freezing in the harsh winter, before the onset of winter, they begin to accumulate sugars in the body and reduce the body’s water temperature to an icy temperature. In addition, the food left in the intestine is also formed as the body temperature drops