J.Am.Chem.Soc.2015,137,4316~4319发展杂环化合物的高效合成方法对药物分子、天然产物及其它功能有机分子的合成具有重要意义.近年来,有机膦催化的环加成反应成为构建杂环化合物的重要工具之一.通过有机膦催化,各国研究者相继完成了多种形式的环加成反应,但有机膦催化的不对称[3+3]环加成反应却一直未被实现.直到最近,中国农业大学应用化学系郭红 J. Am. Chem. Soc. 2015, 137, 4316-4319 The development of efficient synthesis of heterocyclic compounds is of great importance for the synthesis of drug molecules, natural products and other functional organic molecules.In recent years, organophosphine catalyzed cycloaddition The reaction has become one of the most important tools for the construction of heterocyclic compounds.According to the organic phosphine catalysis, many kinds of cycloaddition reactions have been completed in many countries, but the asymmetric [3 + 3] cycloaddition catalyzed by organophosphine has been Until recently, Guo Hong, Department of Applied Chemistry, China Agricultural University