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妊娠期母体血液系统发生一系列生理变化以适应胎儿生长发育,血液总容量增加并有一定程度的血液稀释。如果妊娠期血液不能有效稀释,血红蛋白浓度过高,会引起血液黏度增加,全身血液循环不能适应子宫-胎盘血流的需要。其结果可能导致子宫-胎盘血流量减少、减慢,而引起子宫胎盘缺血缺氧、血管痉挛、血压升高等,而发生妊娠期高血压疾病、小于胎龄儿、早产、低出生体质量、妊娠期糖尿病、死产等。综述妊娠期高浓度血红蛋白对不良妊娠结局的影响,以引起对妊娠期高浓度血红蛋白的重视。
Pregnancy maternal blood system occurs a series of physiological changes in order to adapt to fetal growth and development, increased total blood volume and a certain degree of hemodilution. If the pregnancy blood can not be effectively diluted, hemoglobin concentration is too high, will cause increased blood viscosity, systemic blood circulation can not adapt to the uterus - placental blood flow needs. The result may lead to uterine - placental blood flow decreased, slowing, causing uterine placental ischemia and hypoxia, vasospasm, blood pressure, and so on, and the occurrence of hypertensive disorders of pregnancy, less than gestational age children, premature birth, low birth weight, Gestational diabetes, stillbirth and so on. The effect of high concentration hemoglobin during pregnancy on the outcome of adverse pregnancy was reviewed to arouse the attention of high concentration hemoglobin during pregnancy.