本文报道了利用光学活性的环氧苯乙烷作为起站原料，合成R、S－氟西汀、去甲氟西汀及其类似物的新方法。（R）－环氧苯乙烷与2－甲基－2－羟基丙腈在三乙胺存在下反应，得到4，收率90％；再以二甲基硫醚硼烷复合物还原得到关键中间体3－苯基－3＝羟基丙胺（5）。伯胺5和4－氯－ In this paper, a new method for the synthesis of R, S-fluoxetine, norfluoxetine and their analogues using optically active styrene oxide as a starting material was reported. (R) -phenethyl oxide and 2-methyl-2-hydroxypropionitrile in the presence of triethylamine to give 4, the yield of 90%; and then to dimethyl sulfide borane complex reduction key Intermediate 3-phenyl-3 = hydroxypropylamine (5). Primary amine 5 and 4-chloro-