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目的探讨鼻咽癌放疗患者血清结合唾液含量对鼻咽癌放疗的监测作用。方法用改良硫代巴比妥显色法检测了43例鼻咽癌患者的血清结合唾液酸（LSA）含量及放疗后的改变。结果鼻咽癌患者血清LSA含量为256．92±57．02mg/1明显高于正常对照。Ⅰ、ⅡⅢ期的LSA含量分别为194．50±61．30mg/1、247．63±47．13mg/1、286．79±50．37mg/1，呈明显正相关（r＝0．996）。放疗后血清LSA水平明显下降（P＜0．001），其中未分化癌的LSA阴转率为81．87％，低分化癌为43．75％，有显著性差异。结论血清LSA作为鼻咽癌的一种标记物与其病变程度有关，对疗效追踪、监测病情变化有一定临床意义。
Objective To investigate the role of serum combined with saliva in radiotherapy of nasopharyngeal carcinoma (NPC) in radiotherapy of nasopharyngeal carcinoma. Methods The serum levels of sialic acid (LSA) in 43 patients with nasopharyngeal carcinoma (NPC) and the changes after radiotherapy were detected by modified thiobarbital colorimetric assay. Results Serum LSA levels in patients with NPC were 256.92 ± 57.02 mg / 1, which were significantly higher than those in controls. The LSA contents of Ⅰ and Ⅱ stages were 194.50 ± 61.30mg / 1,247.63 ± 47.13mg / 1,286.79 ± 50.37mg / 1, respectively, showing a significant positive correlation (r = 0.996) . Serum LSA levels decreased significantly after radiotherapy (P <0.001). The prevalence of LSA was 81.87% in undifferentiated carcinoma and 43.75% in poorly differentiated carcinoma with significant difference. Conclusion Serum LSA as a marker of nasopharyngeal carcinoma is related to the degree of its lesion. It has some clinical significance for tracing the curative effect and monitoring the change of disease.