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生理性多胺(腐胺、精脒、精胺、与真核生物细胞增殖有关及稳定核酸结构从1853年Charcot,报道白血病人脾中精胺含量比正常人多之后,人们就注意多胺与细胞恶性增殖现象即癌症间的关系。但在正常生理情况下,人组织和体液中多胺的含量极少(计量单位是10~(-12)mol/g 三氯醋酸沉淀蛋白质,或10~(-9)mol/ml)所以必需使用灵敏的生化测试手段。这个问题只是在近十几年才逐步得到解决。目前文献中大多采用丹磺酰氯(DANS—
Physiological polyamines (putrescine, spermidine, spermine, associated with eukaryotic cell proliferation and stabilizing nucleic acid structure Since 1853, Charcot reported that spermine levels in the spleen of leukemia patients were higher than normal, people were concerned with polyamine The phenomenon of malignant proliferation of cells is the relationship between cancers, but under normal physiological conditions, there are very few polyamines in human tissues and body fluids (10 ~ (-12) mol / g trichloroacetic acid precipitates the protein, or 10 ~ (-9) mol / ml), it is necessary to use sensitive biochemical test methods.This problem has only been solved gradually in recent ten years.Danshyl chloride (DANS-