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目的探讨CTLA4Ig基因转染猪皮治疗中小面积浅Ⅱ度烧伤创面的临床疗效与安全性。方法将自2005年5月~2007年5月我院收治的浅Ⅱ度烧伤患者60例随机分为2组,每组30例。基因转染猪皮治疗组:伤后创面简单清创,去除水疱,用复温后的基因转染猪皮覆盖创面。对照组:创面简单清创,除颜面、会阴部位创面外,均予包扎治疗,保留水疱皮,其后常规换药治疗。结果基因转染猪皮治疗组创面愈合时间5~10d,对照组为8~14d。基因转染猪皮治疗组疼痛明显减轻,未观察到寒战、高热等全身不良反应及局部排斥反应。两组均未出现瘢痕,但对照组部分病例出现色素改变。结论应用基因转染猪皮治疗中小面积浅Ⅱ度烧伤创面能明显缩短创面愈合时间,能明显减轻创面疼痛,减少换药次数,预防色素改变及瘢痕形成。
Objective To investigate the clinical efficacy and safety of CTLA4Ig gene transfection in pigskin for treatment of superficial second degree burn wounds. Methods From May 2005 to May 2007, 60 cases of superficial Ⅱ degree burns admitted to our hospital were randomly divided into two groups (n = 30 in each group). Transfection of pigskin with gene transfection group: simple wound debridement, removal of blisters, wound healing after transfection of pigskin with gene transfection. Control group: simple wound debridement, in addition to the face, perineal wounds, were to bandaging treatment, retaining the blisters skin, and then conventional dressing change treatment. Results The wound healing time of pigs transfected with porcine skin was 5 ~ 10 days, while the control group was 8 ~ 14 days. The pigs treated with gene transfection showed a significant reduction of pain, no systemic adverse reactions such as chills and fever, and local rejection were observed. No scar appeared in both groups, but the pigmentation in some cases in the control group changed. Conclusion The application of gene transfer of pigskin in the treatment of superficial second degree burn wounds can shorten the wound healing time, reduce the wound pain, reduce the number of dressing change, prevent the change of pigment and scar formation.