Jizzakh Province in Uzbekistan is one of the largest irrigated areas in Central Asia without natural drainage. In combination with aridity, climate change and extensive irrigation practices, this has led to the widespread salinization of agricultural land. The aim of this study was to identify opportunities to improve the reclamation status of the irrigated area and how best to effectively use the water resources in Jizzakh Province based on investigations conducted between 1995 and 2016. A database of field measurements of groundwater levels, mineralization and soil salinity conducted by the provincial Hydro-Geological Reclamation Expeditions was used in the study. The total groundwater mineralization was determined using a portable electric conductometer (Progress 1T) and the chloride concentration was determined using the Mohr method. The soil salinity analyses were conducted by applying two different methods: (1) the extraction and assessment of the soluble salt content, and (2) using an SM-138 conductivity sensor applied to a 1:1 mixture of soil sample and water. The analyses of the monitoring results and the salt balance in the irrigation water–soil–drainage water system clearly demonstrated that the condition of the irrigated land in the province was not significantly improved. Under these conditions, the stability of crop yields is achieved mainly through the use of large volumes of fertilizer. However, excess amounts of mineral fertilizers can also cause the salinization of soils. The average groundwater salinization value in most of the irrigated land (75.3％) fluctuated between 1.1 and 5.0 g/L, while the values were less than 1.0 g/L in 13.1％ of the land and in the range of 5.1–10.0 g/L in 10.5％ of the land. During the period of 1995–2016 the salinization level of the irrigated land in Jizzakh Province increased slightly and the area could be divided into the following classes: no salinity (17.7％ of the total area), low salinity (51.3％), moderate salinity (29.0％), and high salinity (2.0％). Detailed studies of the salt balance in irrigated land, the impact of climate change, increased fertilizer use, and repeated remediation leaching on the groundwater level and mineralization should be conducted in the future, due to the possibility of accelerated salinization, fertility decline, and reduced yields of agricultural crops.