1956年Schuknechte已介绍鼓室内注入氨基甙类抗生素治疗梅尼埃病,因链霉素易引致感音神经性聋而未获推广。自庆大霉素(GM)的出现后上述方法又受重视,因GM对内耳的毒性主要是有剂量依赖的前庭毒性,高剂量才损害耳蜗。前庭器的暗细胞是内淋巴液产生地之一,暗细胞比毛细胞对GM的毒 1956 Schuknechte has introduced the tympanic injection of aminoglycoside antibiotics Meniere’s disease, due to streptomycin-sensitive sensorineural hearing loss without promotion. Since the emergence of gentamicin (GM) and the above methods have been taken seriously because of the toxicity of GM on the inner ear is mainly dose-dependent vestibular toxicity, high doses before damage to the cochlea. The dark cells of the vestibular device are one of the sources of endolymphatic fluid, and dark cells are more toxic than GM cells by hair cells