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目的评价乙酰半胱氨酸泡腾片对间质性肺疾病(ILD)的治疗效果。方法筛选了临床确诊的ILD患者56例,分为治疗组和对照组,对照组使用激素治疗,治疗组在激素治疗基础上联合乙酰半胱氨酸泡腾片治疗。观察不同组间的症状缓解率、肺部病灶面积变化及肺功能的变化。结果 3个月后评价治疗效果,治疗组较与照组相比,患者症状缓解率、肺部病灶变化及肺功能变化都有明显改善,两组之间差异有统计学意义(P<0.05)。结论乙酰半胱氨酸泡腾片对肺间质纤维化具有明显的治疗效果,口服治疗使用方便而且不良反应小,可以作为肺间质疾病的有效治疗方法。
Objective To evaluate the therapeutic effect of acetylcysteine effervescent tablets on interstitial lung disease (ILD). Methods Fifty - six patients with clinically diagnosed ILD were screened and divided into treatment group and control group. The control group was treated with hormone therapy. The treatment group was treated with acetylcysteine effervescent tablets on the basis of hormone therapy. Symptomatic remission rates, changes in lung lesion area, and changes in lung function were observed. Results After 3 months, the treatment effect was evaluated. Compared with the control group, the symptoms relieved rate, pulmonary lesions and lung function in the treatment group were significantly improved (P <0.05) . Conclusion Acetylcysteine effervescent tablet has obvious therapeutic effect on pulmonary interstitial fibrosis. Oral treatment is easy to use and has a small adverse reaction. It can be used as an effective treatment for interstitial lung disease.