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本实验用昆明种雄性小鼠92只(体重22±3g),随机分成用药组和对照组。用药组肌注注维生素E,对照组注射相应的赋形剂。用药组血清维生素E含量高于对照组一倍。两组动物同时在加压舱内用压缩空气以每分钟2Kgf/cm~2的速率加压到14Kgf/cm~2,暴露50分钟后,用7分钟减到常压。结果表明:用药组动物出舱后发病率、重病率及死亡率明显地低于对照组;减压后循环血小板的减少也少于对照组。这说明维生素E对预防小鼠实验性减压病有一定作用。本实验为维生素E预防人体减压病的研究提供了初步的实验资料。
In this experiment, 92 Kunming male mice weighing 22 ± 3g were randomly divided into treatment group and control group. Medication group muscle injection of vitamin E, the control group injected the corresponding excipients. The level of serum vitamin E in treatment group was higher than that in control group. At the same time, the two groups of animals were pressurized to 14 Kgf / cm ~ 2 at a rate of 2 Kgf / cm ~ 2 per minute in the pressurized chamber with compressed air. After exposure for 50 minutes, the pressure was reduced to normal pressure in 7 minutes. The results showed that the incidence, serious morbidity and mortality of the animals in the treatment group were significantly lower than those in the control group after they got out of the capsule. The reduction of circulating platelets after decompression was also less than that in the control group. This shows that vitamin E to prevent experimental decompression in mice have a role. The experiment for the prevention of vitamin E in the study of human decompression provides preliminary experimental data.