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目的:探讨女性结肠癌患者癌组织中ER和uPA蛋白的表达及其与临床病理特征的关系。方法:采用免疫组织化学技术检测20例癌旁正常结肠粘膜、30例结肠腺瘤和60例结肠腺癌中ER和uPA蛋白的表达,分析其表达与结肠癌的临床分期、病理类型及有无淋巴结转移的关系。结果:ER在正常粘膜组、结肠腺瘤组及结肠癌组的阳性表达率分别为100.00%、86.67%、38.33%,uPA在正常粘膜组、结肠腺瘤组及结肠癌组的阳性表达率分别为5.00%、30.00%、81.67%,ER和uPA在正常粘膜组与结肠腺瘤组及结肠癌组相比较差异均有统计学意义(P<0.01)。ER和uPA的阳性表达率与临床分期、病理类型及有无淋巴结转移均有明显相关性(P<0.01),ER和uPA在结肠癌的表达中呈负相关性(P<0.01)。结论:在女性结肠癌组织中ER蛋白的下调和uPA蛋白的上调可能在结肠癌浸润和转移中起重要作用,二者的联合检测可成为结肠癌治疗的新靶点及判断预后的指标。
Objective: To investigate the expression of ER and uPA in the cancer tissues of female patients with colorectal carcinoma and its relationship with clinicopathological features. Methods: The expression of ER and uPA in 20 cases of colorectal mucosa, 30 cases of colorectal adenoma and 60 cases of colon adenocarcinoma were detected by immunohistochemical technique. The expression of ER and uPA in colon adenocarcinoma was analyzed by immunohistochemistry. The clinical stages, pathological types, Lymph node metastasis. Results: The positive expression rates of ER in normal mucosa, colon adenoma and colon cancer were 100.00%, 86.67% and 38.33% respectively. The positive rates of uPA in normal mucosa, colon adenoma and colon cancer were (5.00%, 30.00% and 81.67% respectively). The difference of ER and uPA between normal mucosa group and colon adenoma group and colon cancer group were statistically significant (P <0.01). The positive expression rates of ER and uPA were significantly correlated with clinical stage, pathological type and lymph node metastasis (P <0.01). The expression of ER and uPA in colon cancer was negatively correlated (P <0.01). Conclusion: The down-regulation of ER protein and upregulation of uPA in colon cancer tissues may play an important role in the invasion and metastasis of colon cancer. The combined detection of ER and uPA may become a new target for the treatment of colon cancer and an indicator of prognosis.