细胞内物质运输是细胞发挥正常生物学功能的基础.驱动蛋白可作为运送细胞内物质的载体,通过与不同的骨架蛋白结合以识别不同的分子货物,从而参与这些分子货物下游的生物学效应.没有运输活性的驱动蛋白也可以通过其自身对某些分子信号通路的调节而发挥其功能.大量研究表明,驱动蛋白广泛地参与了多种疾病的发生发展过程,如神经性疾病、代谢性疾病、肾病、癌症等.本文将对近年来诸多关于驱动蛋白与疾病的研究进行综述. Transporting intracellular material is the basis for the cells to exert their normal biological functions.Kinesins can serve as carriers for transporting intracellular substances and can participate in biological effects downstream of these molecular cargoes by recognizing different molecular cargoes by binding to different backbone proteins. Kinesin, which is not transportable, can also function through the regulation of some molecular signaling pathways.A large number of studies have shown that kinesins are widely involved in the development and progression of various diseases such as neurological diseases, metabolic diseases , Nephropathy, cancer, etc. This article reviews many recent studies on kinesins and diseases.