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目的探讨双环醇片干预耐药性结核治疗所致药物性肝炎的临床疗效。方法按随机数字表法将80例患者分为观察组与对照组,各40例。观察组患者给予双环醇片治疗,对照组患者给予护肝片治疗。结果治疗后,观察组丙氨酸氨基转移酶、天门冬酸氨基转移酶及总胆汁酸水平显著低于对照组(P<0.05),丙二醛(MDA)水平显著低于对照组(P<0.05)超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)水平显著高于对照组(P<0.05),腹胀、肝区不适、食欲减退及肝肿大的发生率显著低于对照组(P<0.05)。结论双环醇片治疗耐药性结核治疗所致肝损伤,能显著降低肝脏损伤,减轻机体氧化反应,改善临床症状,值得临床推广。
Objective To investigate the clinical efficacy of bicyclic alcohol tablets in preventing drug-induced hepatitis caused by drug-resistant tuberculosis. Methods According to random number table method, 80 patients were divided into observation group and control group, 40 cases each. Patients in the observation group were treated with bicycloalcohol tablets and patients in the control group were given hepatoprotective tablets. Results After treatment, the levels of alanine aminotransferase, aspartate aminotransferase and total bile acid in the observation group were significantly lower than those in the control group (P <0.05) and the levels of malondialdehyde (MDA) in the observation group were significantly lower than those in the control group (P < 0.05). The levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were significantly higher than those of the control group (P <0.05), bloating, liver discomfort, loss of appetite and hepatomegaly The rate was significantly lower than that of the control group (P <0.05). Conclusion Bicyclometacin can effectively reduce liver damage, alleviate the body’s oxidation reaction and improve clinical symptoms, which is worthy of clinical promotion.