The aim of this work was to establish a method that the 6 synthetic pigments in compound wine were determined by HPLC.The synthetic pigments in the compound wines were extracted by liquid-liquid extraction, separated by C_(18) symmetry chromatographic column, with 0.02 mol/L ammonium acetate and methanol as the mobile phase with gradient elution, the sample was detected by diode array detector.The test results showed that the artificial synthetic pigment in 0.20-20 μg/L range of concentration had a good linear relationship(r>0.999 2), the detection limits were 0.000 16-0.001 04 g/kg, the recovery rates were 82.0%-97.0%, the relative standard deviation were 0.7%-3.5%. The method was simple, rapid, high sensitivity, good separation effect and can be widely used in the daily inspection work. The aim of this work was to establish a method that the 6 synthetic pigments in compound wine were determined by HPLC. The synthetic pigments in the compound wines were extracted by liquid-liquid extraction, separated by C 18 symmetry chromatographic column with 0.02 mol / L ammonium acetate and methanol as the mobile phase with gradient elution, the sample was detected by diode array detector. The test results showed that artificial synthetic pigment in 0.20-20 μg / L range of concentration had a good linear relationship (r > 0.999 2), the detection limits were 0.000 16-0.001 04 g / kg, the recovery rates were 82.0% -97.0%, the relative standard deviation were 0.7% -3.5%. The method was simple, rapid, high sensitivity, good separation effect and can widely used in the daily inspection work.