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目的：观察人重组ＩＬ－８ 在体内对新西兰家兔外周血白细胞的动员作用及其时间动力学。方法：按１０μｇ／ｋｇ 的剂量在兔静脉内注射ｒｈＩＬ－８ ，收集不同时间的外周血，显微镜观察各种白细胞数量的变化。结果：ＩＬ－８ 可升高外周血的白细胞数量，尤其是中性粒细胞的数量，从２．６６ ×１０９／Ｌ升高至５ ．９９×１０９／Ｌ。ＩＬ－ ８ 动员的中性粒细胞以幼稚中性粒细胞（带状核）为主。ＩＬ－８ 对中性粒细胞动员作用迅速，６０ｍｉｎ 时达到高峰，但持续时间短，１８０ｍｉｎ 时已接近正常水平。结论：ＩＬ－ ８ 可显著升高外周血中性粒细胞数，而且是一种快速、安全的动员剂。
OBJECTIVE: To observe the mobilization and time kinetics of human recombinant interleukin-8 in peripheral blood leukocytes in New Zealand rabbits in vivo. Methods: The rhIL-8 was injected intravenously into rabbits at the dose of 10μg / kg. Peripheral blood was collected at different times, and the changes of the number of leukocytes were observed under a microscope. Results: IL-8 increased the number of white blood cells in peripheral blood, especially the number of neutrophils, from 2.66 × 109 / L to 5. 99 × 109 / L. The neutrophils mobilized by IL-8 are predominantly naive neutrophils (ribbon nuclei). IL-8 on the neutrophil mobilization rapid, peaked at 60min, but the duration is short, 180min was close to normal levels. Conclusion: IL-8 can significantly increase the number of peripheral blood neutrophils, but also a fast and safe mobilization agent.