编码T细胞抗原受体(TCR)的β与α链的基因分别定位于染色体7q3及14q1区带。在恶性T细胞疾病中,已观察到这些染色体区带上相应基因的结构改变。这些结果提示,T细胞恶性疾病与受累细胞的α:β基因的结构改变可能密切相关。另一类TCR基因簇γ基因定位于染色体7p1区带,其编码蛋白功能尚不明。由于在未成熟胸腺细胞有较高表达,而在成熟胸腺细胞或T细胞中不表达或仅有低 The genes encoding the beta and alpha chains of the T cell antigen receptor (TCR) are located on the 7q3 and 14q1 chromosomes, respectively. In malignant T cell disease, structural changes in the corresponding genes in these chromosomal bands have been observed. These results suggest that T-cell malignancies may be closely related to the structural changes of the α: β gene in affected cells. Another type of TCR gene cluster γ gene located in the chromosome 7p1 band, the function of its encoded protein is not yet known. Due to the higher expression in immature thymocytes and not in mature thymocytes or T cells or only low