论文部分内容阅读
心率是衡量冠状动脉疾病（CAD）乃至心力衰竭病理生理的重要参考指标之一。伊伐布雷定是一种特异性选择阻断窦房结 If 电流的新型抗心绞痛和抗心肌缺血药。其主要的作用机制为在不影响心功能参数（包括心肌收缩力、心肌传导及其他血流动力学等）的情况下减慢心率，同时在改善稳定型 CAD 症状及减轻慢性心力衰竭心肌缺血中起至关重要的作用。该文将对伊伐布雷定的药理特性、药代动力学及 CAD 和心力衰竭的治疗研究予以综述。“,”Heart rate is an important index for the pathophysiology of both coronary artery disease (CAD) and heart failure.Ivabradine is an anti-anginal and anti-ischemic agent,which selectively and specifically inhibits the If current in the sino-atrial node and provides pure heart rate reduction without altering other cardiac parameters( myocardial contractility,cardiac conduction and other hemodynamic parameters).It plays an important role in improve the symptoms of stable CAD and relieve chronic heart failure myocardial ischemia.Here is to make a review of the pharmacological properties,pharma-cokinetics and the clinical curative effect of ivabradine in the treatment of CAD and heart failure .