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目的探讨宫颈癌患者组织及血清血管内皮生长因子的变化情况。方法选取2012年5月～2013年4月于本院诊治的39例宫颈癌患者为观察组,39例健康体检者为对照组,将两组的组织及血清VEGF-C、VEGF-D进行比较,另将不同FIGO分期者进行比较。结果观察组的组织VEGF-C、VEGF-D阳性率及血清VEGF-C、VEGF-D水平均高于对照组,且Ⅲ～Ⅳ期高于Ⅰ～Ⅱ期患者,P均<0.05,均有显著性差异。结论宫颈癌患者组织及血清血管内皮生长因子均呈现高表达的状态,与其血管的增殖及转移有一定的关系。
Objective To investigate the changes of tissue and serum vascular endothelial growth factor in patients with cervical cancer. Methods Thirty-nine cervical cancer patients treated in our hospital from May 2012 to April 2013 were selected as observation group and 39 healthy individuals as control group. The levels of VEGF-C and VEGF-D were compared between the two groups , The other will be different FIGO staging were compared. Results The positive rates of VEGF-C, VEGF-D and the levels of VEGF-C and VEGF-D in the observation group were higher than those in the control group, and were significantly higher than those in stage Ⅰ ~ Ⅱ Significant difference. Conclusion The expression of vascular endothelial growth factor (VEGF) and tissue in patients with cervical cancer are highly expressed, which is related to their proliferation and metastasis.