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目的分析结肠黑变病(MC)的病因及与其结肠肿瘤的关系。方法对78例结肠黑变病患者的临床资料进行回顾性分析。结果便秘患者56例(23.1%),其中长期服用泻药患者38例(48.7%),无明确服泻药史患者18例(23.1%);合并有腺瘤样息肉16例;合并结肠癌1例。结论便秘及服用泻药是导致MC发生的重要因素;泻剂中多为蒽醌类。结肠黑变病与结肠肿瘤的关系值得进一步研究。
Objective To analyze the etiology of colitis mellitus (MC) and its relationship with colon cancer. Methods The clinical data of 78 cases of melanosis patients were retrospectively analyzed. Results Fifty-six patients (23.1%) had constipation, including 38 patients (48.7%) taking laxatives for a long time and 18 patients (23.1%) having no history of laxatives. There were 16 patients with adenomatous polyps and 1 patient with colon cancer. Conclusions Constipation and taking laxatives are the important factors leading to the occurrence of MC. Laxatives are mostly anthraquinones. The relationship between colorectal melanosis and colon cancer deserves further study.