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目的 :通过对肾综合征出血热 (HFRS)监测分析 ,掌握全省HFRS的流行规律 ,控制其暴发流行 ,进一步降低该病的发病率 ,为制定防制措施提供依据。方法 :采用直接免疫荧光 (FAT)法 ,检测鼠肺HV抗原 ;采用间接免疫荧光 (IFAT)法检测HFRS病人、健康人血清及鼠血中HV抗体。结果 :1997～ 2 0 0 0年全省共发病 90 41例 ,年均发病率为 5 .0 8/ 10万 ,死亡 48人 ,病死率为 0 .5 3%。病例仍主要分布在沿钱塘江两岸的浙东和浙西丘陵区 ,浙南山区次之 ,浙北平原区和海岛区病例较少 ,全省 11个地市均有发病 ,以浙东和浙西丘陵区的绍兴、宁波、台州、衢州、杭州和金华 6市发病最多。宿主动物野外以黑线姬鼠为优势种 ,占 80 .79% ,室内以褐家鼠为优势种 ,占 80 .91%。结论 :需要进一步加大监测力度 ,同时接种HFRS疫苗
OBJECTIVE: To monitor and analyze the epidemic of hemorrhagic fever with renal syndrome (HFRS), master the epidemic pattern of HFRS in the whole province, control the outbreak of HFRS, further reduce the incidence of HFRS, and provide the basis for making prevention and control measures. Methods: The mouse lung HV antigen was detected by direct immunofluorescence (FAT) method. The HV antibodies in HFRS, healthy human and rat blood were detected by indirect immunofluorescence (IFAT). Results: From 1997 to 2000, a total of 9041 cases were found in the province, with an average annual incidence of 5.08 / 100 000, 48 deaths and a mortality rate of 0.53%. The cases are still mainly distributed in the eastern Zhejiang and western Zhejiang hilly areas along the banks of the Qiantang River, followed by the mountainous areas in the south of Zhejiang Province, fewer cases in the plain and island areas of the northern Zhejiang Province, and 11 cities in the province have incidence. West Hill area of Shaoxing, Ningbo, Taizhou, Quzhou, Hangzhou and Jinhua 6 most incidence. Host animals in the wild Apodemus heterophylla is the dominant species, accounting for 80.79%, indoors to Rattus norvegicus dominant species, accounting for 80.91%. Conclusion: There is a need to further intensify monitoring efforts while vaccinating against HFRS