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目的:探讨人细小病毒B19感染与成人特发性血小板减少性紫癜发病的关系。方法:采用酶联免疫吸附法对50例成人特发性血小板减少性紫癜患者和30例健康成人的血清标本进行人细小病毒B19-IgM,IgG及血小板相关抗体检测。结果:50例特发性血小板减少性紫癜患者血清中人细小病毒B19抗体总阳性率56%(28/50),30例健康成人3例人细小病毒B19-IgG为阳性(10%),2组间差异有统计学意义(IgG组P<0.01,IgM组P<0.05)。病毒感染阳性与阴性患者的血小板相关抗体差异无统计学意义(P>0.05)。结论:成人特发性血小板减少性紫癜患者人细小病毒B19抗体总阳性率高,以IgG抗体为主,符合成人以慢性型特发性血小板减少性紫癜为主的特点。成人中人细小病毒B19感染与血小板相关抗体无明显相关性,提示成人特发性血小板减少性紫癜发病因素的复杂性。
Objective: To investigate the relationship between human parvovirus B19 infection and adult idiopathic thrombocytopenic purpura. Methods: Serum samples of 50 idiopathic idiopathic thrombocytopenic purpura patients and 30 healthy adults were detected by enzyme-linked immunosorbent assay for the detection of human parvovirus B19-IgM, IgG and platelet-associated antibodies. Results: The total positive rate of human parvovirus B19 antibody in 50 patients with idiopathic thrombocytopenic purpura was 56% (28/50). The positive rate of B19-IgG was 3 in 30 healthy adults (10%) and 2 The difference between the two groups was statistically significant (P <0.01 in IgG group and P <0.05 in IgM group). There were no significant differences in platelet-associated antibodies between patients with positive and negative viral infections (P> 0.05). Conclusion: The total positive rate of human parvovirus B19 antibody in adult idiopathic thrombocytopenic purpura patients is mainly IgG antibody, which is in line with adult characteristics of chronic idiopathic thrombocytopenic purpura. There was no significant correlation between infection of human parvovirus B19 and platelet-associated antibodies in adults, suggesting the complexity of the pathogenesis of adult idiopathic thrombocytopenic purpura.