论文部分内容阅读
作者在光镜下检查了雄性大鼠给镉(Cd)和(或)硒(Se)后睾丸、肝、肾和心脏的形态学改变;同时(?)Zeeman效应石墨炉法和原子荧光法分别测定了饮水、饲料和全血Cd和Se的含量。结果表明:给Cd后大鼠睾丸组织萎缩,生精细胞数目减少和坏死;肾/体比值从空白对照(C)组的0.74±0.03增至实验(E2)组的0.83±0.03(P<0.01);心/体比值从C组的0.36±0.04增至E2组的0.41±0.02,P<0.01;Cd在血液中的蓄积增加,从C组的2.3±1.5mg/kg增至E2组的167.5±33.8mg/kg(P<0.01)。这些形态学的改变和给Cd剂量有关。经口补充小剂量Se(0.05 mg kg)可拮抗Cd所致的睾丸损伤及脏/体比值的异常。
The authors examined the morphological changes of the testis, liver, kidney and heart after cadmium (Cd) and (or) selenium (Se) administration to male rats under light microscopy; simultaneously (?) Zeeman effect graphite furnace and atomic fluorescence spectrometry The contents of Cd and Se in drinking water, feed and whole blood were determined. The results showed that after Cd administration, the rat testicular tissue was atrophic and the number of spermatogenic cells decreased and necrosis; the kidney/body ratio increased from 0.74±0.03 in the blank control group (C) to 0.83±0.03 in the experimental (E2) group (P<0.01). The heart/body ratio increased from 0.36±0.04 in group C to 0.41±0.02 in group E2, P<0.01; the accumulation of Cd in blood increased from 2.3±1.5 mg/kg in group C to 167.5 in group E2. ± 33.8 mg/kg (P < 0.01). These morphological changes are related to the dose of Cd. Oral supplementation of small doses of Se (0.05 mg kg) antagonized Cd-induced testicular damage and abnormalities of the visceral/body ratio.