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用酸性牛神经肽1(ABNP1)进行了对抗吗啡引起小鼠竖尾的实验研究和ABNP1的成瘾实验。结果表明:05g/kg的ABNP1可以100%地抑制吗啡引起的小鼠竖尾;025%的ABNP1可50%地抑制吗啡引起的小鼠竖尾;0125g/kg的ABNP1可10%地抑制吗啡引起的小鼠竖尾。每只小鼠每d给于050,025和012g/(kg·d)的ABNP1,连续10d给药之后,给于5mg/kg的纳洛酮催瘾后作跳台试验。结果:无一只小鼠跳下跳台。提示:ABNP1具有抑制吗啡的兴奋作用且在实验浓度内不具有成瘾性。
With acidic bovine neuropeptide 1 (ABNP 1) against morphine-induced mice in the tail of the experimental study and ABNP 1 addiction experiments. The results showed that: 05g / kg of ABNP 1 can 100% inhibition of morphine induced mice tail; 0 25% of ABNP 1 50% inhibition of morphine induced mice tail; 0 125g / kg of ABNP 1 10% inhibition of morphine-induced mouse tail. Each mouse given 0 50, 0 25 and 0 12g / (kg · d) of ABNP 1, after 10 consecutive days of administration, to 5mg / kg of naloxone addicted to make platform for jumping test. Results: None of the mice jumped off the platform. Tip: ABNP 1 inhibited the excitement of morphine and did not addictive within the experimental concentration.