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对各种危重患者出现的急性肾功能衰竭(ARF)不仅要使肾功能得到改善,且应在建立强有力的综合管理基础上进行肾功能衰竭的治疗。 急性肾功能衰竭的发病机理复杂,其中,以肾血流减少、肾内肾素-血管紧张素增多导致肾内小动脉特别是入球小动脉收缩(肾缺血),使肾小球滤过率极度下降,可能是大多数急性肾功能衰竭的主要机理。不同病因的ARF又以不同的机理为主。例如各种毒素肾毒性药物可直接造成肾小管坏
Acute renal failure (ARF) in critically ill patients requires not only improvement of renal function but also treatment of renal failure based on a strong and comprehensive management. The pathogenesis of acute renal failure is complex. Among them, the reduction of renal blood flow and renal renin-angiotensin synthesis lead to the contraction of the renal arterioles, especially the arteriolar intima (renal ischemia), glomerular filtration Extremely decreased rates may be the primary mechanism of most acute renal failure. ARF different causes of different mechanisms. For example, various toxins nephrotoxic drugs can directly cause tubular damage