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目的:研究探讨卡介菌多糖核酸制剂对哮喘患者发生的上呼吸道感染的预防作用。方法:对我校门诊部2010年至2012年诊治的64例哮喘患者随机分为两组,治疗组36例,应用卡介菌多糖核酸制剂;对照组28例,观察随访6个月。对治疗组在治疗前以及治疗一个月、六个月时的血清免疫球蛋白水平及CD4﹢水平进行测定。结果:治疗组的感染人数及发作天数均明显低于对照组,血中CD4﹢水平治疗组较对照组明显升高,IgG、IgA均有下降,IgM变化不大。结论:使用卡介菌多糖核酸制剂,能够提高细胞的免疫功能,进而可以显著地降低哮喘患者发生上呼吸道感染的可能性。
Objective: To investigate the preventive effect of BCG polysaccharide nucleic acid preparation on upper respiratory tract infection in asthmatic patients. Methods: Sixty-four asthma patients diagnosed and treated in our clinic between 2010 and 2012 were randomly divided into two groups. The treatment group received 36 cases of BCG polysaccharide nucleic acid preparations. The control group of 28 cases were followed up for 6 months. Serum immunoglobulin levels and CD4 + levels of the treatment group before treatment and one month and six months after treatment were measured. Results: The number of infection and the number of seizure days in the treatment group were significantly lower than those in the control group. The levels of CD4 + in the blood of the treatment group were significantly higher than those in the control group, but both IgG and IgA were decreased. Conclusion: The use of BCG polysaccharide nucleic acid preparations can improve the immune function of cells, which can significantly reduce the possibility of upper respiratory tract infection in asthmatic patients.