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探讨重复肝动脉栓塞化疗（ＴＡＥ）是否加重肝癌患者肝硬化的形成。方法我们对４０例经三次．ＴＡＥ治疗的原发性肝癌（ＰＨＣ）患者，测定了治疗前后透明质酸（ＨＡ）、层粘蛋白（ＬＮ）、人ｉｌｌ型前胶原（ｈｐｅⅢ）和四型胶原（Ⅳ．Ｃ）的含量。结果首次ＴＡＥ治疗后与ＴＡＥ前相比，上述四项指标差异无显著性意义（Ｐ＞０．０５）；从第二次ＴＡＥ治疗后，可见四项肝纤维化指标均有升高（Ｐ＜０．０５），以第三次ＴＡＥ后升高最为明显（Ｐ＜０．０１）。结论重复ＴＡＥ治疗常可加重患者的肝损害，应引起足够的重视。
To investigate whether repeat hepatic artery embolization chemotherapy (TAE) aggravates the formation of liver cirrhosis in patients with liver cancer. Method we have for 40 cases three times. In TAE-treated patients with primary liver cancer (PHC), the levels of hyaluronic acid (HA), laminin (LN), human precollagen (hpeIII), and collagen IV (IV.C) were determined before and after treatment. Results After the first TAE treatment, compared with before TAE, there was no significant difference in the above four indicators (P>0.05); after the second TAE treatment, all four hepatic fibrosis indexes increased (P< 0.05), the most significant increase after the third TAE (P <0.01). Conclusion Repeated TAE treatment often aggravates liver damage in patients and should be given enough attention.