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目的:对我院不同年龄新生儿感染性肺炎的病原菌及药敏试验结果进行分析,为临床合理使用抗菌药物提供依据。方法:回顾性分析2009年1月至2013年9月我院儿科住院治疗的683例新生儿肺炎患儿痰培养及药敏试验结果。结果:683例患儿痰培养阳性者188例,占27.5%。早期新生儿组G-菌感染多见,晚期新生儿组G+菌感染多见。最常见的细菌为大肠埃希菌、肺炎链球菌、葡萄球菌属及流感嗜血杆菌。两种细菌混合感染者共43例,以晚期新生儿组多见。常见病原菌对头孢他啶、阿米卡星、环丙沙星和氨曲南、亚胺培南较为敏感。结论:大肠埃希菌是四川成都双流地区新生儿肺炎最常见病原菌。头孢他啶在四川成都双流地区新生儿肺炎中敏感率高、安全性好,可考虑作为四川成都双流地区新生儿肺炎治疗时首选药物。
OBJECTIVE: To analyze the pathogenic bacteria and drug susceptibility test results of neonatal pneumonia at different ages in our hospital, and provide the basis for the rational use of antibacterial drugs in clinical practice. Methods: The sputum culture and drug sensitivity test results of 683 neonates with pneumonia in our hospital from January 2009 to September 2013 were retrospectively analyzed. Results: There were 188 cases of sputum culture positive in 683 children, accounting for 27.5%. Early neonatal G- bacterial infection more common, late neonatal G + bacterial infection more common. The most common bacteria are Escherichia coli, Streptococcus pneumoniae, Staphylococcus and Haemophilus influenzae. A total of 43 cases of mixed infection of two bacteria to late neonatal group more common. Common pathogens are more sensitive to ceftazidime, amikacin, ciprofloxacin and aztreonam, imipenem. Conclusion: Escherichia coli is the most common pathogen of neonatal pneumonia in Shuangliu, Chengdu, Sichuan Province. Ceftazidime in Chengdu, Sichuan Shuangliu neonatal pneumonia in the high sensitivity and safety, may be considered as the preferred drug treatment of neonatal pneumonia in Shuangliu area of Chengdu, Sichuan Province.