目的　探讨应用羟基喜树碱 (HCPT)进行膀胱内灌注 ,预防浅表性膀胱癌术后复发的疗效和安全性。方法　对保留膀胱手术治疗后的 89例浅表性膀胱癌患者 ,采用HCPT(10mg 2 0ml)进行膀胱内灌注治疗。结果　经平均随访 2 7.9个月 ,89例患者中复发 19例 (2 1.3% ) ,且并发症和副作用较小。结论　HCPT膀胱内灌注预防浅表性膀胱癌术后复发 ,具有较好的效果 ,毒副作用少而轻 Objective To investigate the efficacy and safety of intravesical instillation of hydroxycamptothecin (HCPT) for the prevention of postoperative recurrence of superficial bladder cancer. Methods Eighty-nine patients with superficial bladder cancer after bladder surgery were treated by intravesical instillation with HCPT (10mg 20ml). Results After a mean follow-up of 2 7.9 months, 19 of 89 patients (21.3%) had fewer complications and fewer side effects. Conclusion Intravesical instillation of HCPT can prevent postoperative recurrence of superficial bladder cancer with good effect and less toxic side effects