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目的研究脑脊液置换联合尼莫地平、地塞米松鞘内注射治疗蛛网膜下腔出血(SAH)的治疗作用。方法将127例SAH患者随机分为试验组和对照组;对照组应用镇静、止痛、药物(EACA、尼莫地平片)等常规治疗方法,试验组在常规治疗的基础上,应用腰穿脑脊液置换和鞘内注射尼莫地平、地塞米松。结果SAH的头痛症状以及脑积水、蛛网膜粘连、脑血管痉挛等主要并发症的发生率、死亡率,试验组明显少于对照组,经统计学处理,有统计学差异。结论脑脊液置换联合尼莫地平、地塞米松鞘内注射治疗蛛网膜下腔出血,可明显降低SAH主要并发症的发生率和死亡率,其方法简便,效果可靠,有非常实用的临床价值。
Objective To study the therapeutic effect of cerebrospinal fluid replacement combined with nimodipine and dexamethasone intrathecal injection on patients with subarachnoid hemorrhage (SAH). Methods A total of 127 patients with SAH were randomly divided into experimental group and control group. The control group was given conventional therapy such as sedation, analgesia and drugs (EACA, nimodipine). On the basis of routine treatment, And intrathecal nimodipine, dexamethasone. Results The incidence of headache, hydrocephalus, arachnoid adhesions and cerebral vasospasm in SAH were significantly lower than those in the control group. There was statistical difference between the two groups. Conclusion Cerebrospinal fluid replacement combined with nimodipine and dexamethasone intrathecal injection for subarachnoid hemorrhage can significantly reduce the incidence and mortality of major complications of SAH. The method is simple, reliable and has very practical clinical value.