胸腺肽-α1对脓毒症患者血清IL-8及IL-10的调节作用

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目的观察胸腺肽-α1对脓毒症患者免疫紊乱的调节作用及对预后的影响。方法采用单中心前瞻性随机对照研究,纳入2015年7月-2017年1月东莞市第三人民医院重症医学科收治的脓毒症患者70例,按是否使用胸腺肽-α1(Tα1)分为药物组(n=35)和安慰剂组(n=35)。采用ELISA法测定两组患者治疗后第1天(d1)、第5天(d5)和第10天(d10)的血清IL-8和IL-10浓度,计算IL-8/IL-10比值;记录患者入院时的APPACHEⅡ评分及ICU住院时间,分析好转率;检测两组血清白细胞计数(WBC)及
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