【摘 要】
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The assembly of biomacromole particles with artificial solid matrixes to fabricate hybrid composites has been demonstrated as an efficient strategy to promote both components\' applications.Elaborating matrixes as well as appropriate assembly method is
【机 构】
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State Key Laboratory of Medicinal Chemical Biology,College of Pharmacy,Nankai University,Tianjin 300
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The assembly of biomacromole particles with artificial solid matrixes to fabricate hybrid composites has been demonstrated as an efficient strategy to promote both components\' applications.Elaborating matrixes as well as appropriate assembly method is essential for optimal performances of the obtained natural-artificial composites.Herein,we fabricated the Cyt c@COF-42-B microcapsule through a sacrificial templating method and researched their adjustable biocatalysis by precisely adjusting the microenviron-ments of these assembled enzyme@COF particles.As a result,the hydrophobicity and mass transfer of the COF microcapsule can be controlled by modifying the different amounts of PEG moieties,thus improving the composite\'s bioactivity.We found that compared with pristine Cyt c@COF-42-B without PEG,the Cyt c@COF-42-B-PEG exhibited a ～2.2 times higher activity.This study provides a significant step toward designing customizable functional natural-artificial composites for enhanced biomacromolecule\'s activ-ity.
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