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作者对接种3针乙型肝炎疫苗后无应答、应答低下(抗-HBs滴度<10IU/l)及以后随访中抗体滴度降至10IU/l以下者进行了再接种。 212名受试者曾接种过3针乙型肝炎疫苗,包括5μg、10μg 20μg血源疫苗及10μg酵母重组疫苗。均于第0、1和6个月行三角肌注射。接种后情况如下:(1)33人无应答;(2)12人抗体应答低下;(3)167人在随访中抗体滴度<10 IU/l。以前接种血源疫苗者均再接种1剂20μg血源疫苗;22名以前接种酵母重组疫苗者均再接种1剂10μg重组疫苗。结果表明,再接种后,有18%的无应答者及96%的最初有应答者的抗-HBs>10IU
The authors re-vaccinated against 3-dose hepatitis B vaccine without response, low response (anti-HBs titer <10 IU / l), and antibody titers below 10 IU / l at subsequent follow-up visits. 212 subjects had been vaccinated with a 3-dose hepatitis B vaccine, including 5 μg, 10 μg of 20 μg blood vaccine and 10 μg of yeast recombinant vaccine. All animals were injected deltoid at 0, 1 and 6 months. The situation after inoculation was as follows: (1) 33 non-responders; (2) 12 human antibody responses were low; (3) 167 were antibody titers <10 IU / l at follow-up. Before the vaccination of blood-borne vaccine were inoculated with a dose of 20 g of blood-borne vaccine; 22 previously vaccinated yeast recombinant vaccine were re-vaccinated a 10 g recombinant vaccine. The results showed that after re-vaccination, 18% of non-responders and 96% of respondents had anti-HBs> 10IU