论文部分内容阅读
目的:对本院儿科1994～2006年临床报告的179例儿童β-内酰胺类抗生素的不良反应(ADR)进行分析。方法:179例β-内酰胺类抗生素ADR,按照不良反应类别进行归纳、统计和分析。结果:同期儿科ADR临床报告共378例,其中β-内酰胺类抗生素占47.35%(179/378)。涉及青霉素类112例,占62.57%;头孢菌素类67例,占37。43%。共23种药物,其中阿莫西林+克拉维酸钾居首位41例,占22.91%。ADR涉及人体器官10个,其中皮肤粘膜损害146例,占81.56%。其严重程度,轻度23例(占12.85%),中度147例(占82.12%),重度9例(占5.03%)。结论:本次调查报告中,青霉素类ADR所占比例较高,其中阿莫西林+克拉维酸钾居首位;绝大多数涉及皮肤粘膜损害,ADR损害程度以中度为主,但还有些严重不良反应。
Objective: To analyze the adverse reactions (ADR) of 179 children with β-lactam antibiotics in our hospital from 1994 to 2006. Methods: 179 cases of β-lactam antibiotics ADR, according to the type of adverse reactions were summarized, statistics and analysis. Results: There were 378 clinical reports of pediatric ADR in the same period, among which β-lactam antibiotics accounted for 47.35% (179/378). 112 cases involved penicillins, accounting for 62.57%; 67 cases of cephalosporins, accounting for 37.43%. A total of 23 kinds of drugs, including amoxicillin + clavulanate in the first 41 cases, accounting for 22.91%. ADR involved 10 human organs, of which 146 cases of skin and mucosal damage, accounting for 81.56%. The severity was mild in 23 cases (12.85%), moderate in 147 cases (82.12%) and severe in 9 cases (5.03%). Conclusion: In this survey, the proportion of penicillin ADR is high, among which amoxicillin and clavulanate are the highest, most of which involve skin and mucosal damage, with moderate degree of ADR damage, but some others Serious adverse reactions.