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目的探讨败血症新生儿C-反应蛋白(CRP)的变化以及CRP在新生儿败血症中的诊断价值。方法对某院26例新生儿败血症患儿(败血症组)及30例正常健康新生儿(对照组)采取散射比浊法测定血清CRP水平,并且同时检测WBC计数及血培养做为对照。结果败血症组患儿血清CRP(56.13±32.87)mg/L、WBC(24.37±7.84)×109/L,明显高于对照组新生儿CRP(5.38±2.11)mg/L、WBC(7.78±1.32)×109/L,两组之间差异有统计学意义(P﹤0.05);败血症组血培养阳性20例,阳性患儿CRP阳性率90.00%,WBC阳性率70.00%,CRP与血培养之间差异无统计学意义(χ2=0.53,P﹥0.05),WBC与血培养之间差异有统计学意义(χ2=4.90,P﹤0.05)。结论 CRP检测有助于协助新生儿败血症的诊断,可为早期诊断提供诊断依据。
Objective To investigate the changes of neonatal C-reactive protein (CRP) in sepsis and the diagnostic value of CRP in neonatal sepsis. Methods Serum CRP levels were measured by nephelometry in 26 neonates with sepsis (sepsis group) and 30 normal healthy newborns (control group) in a hospital. The WBC count and blood culture were taken as control. Results The serum levels of CRP in the sepsis group (56.13 ± 32.87) mg / L and WBC (24.37 ± 7.84) × 109 / L were significantly higher than those in the control group (5.38 ± 2.11 mg / L and 7.78 ± 1.32 mg / × 109 / L, the difference between the two groups was statistically significant (P <0.05); sera group blood culture positive in 20 cases, positive children CRP positive rate of 90.00%, WBC positive rate of 70.00%, CRP and blood culture differences There was no statistical significance (χ2 = 0.53, P> 0.05). The difference between WBC and blood culture was statistically significant (χ2 = 4.90, P <0.05). Conclusion CRP test can help to diagnose neonatal sepsis and provide a diagnostic basis for early diagnosis.