用对甲苯磺酸-2,3-丙酮缩甘油酯(2)与乙酰乙酸乙酯盐、碳酸二乙酯反应,制备β-酮酯类衍生物1.以(±)-1,2-丙酮缩甘油为起始物,经对甲苯磺酰化、亲核取代、脱羧等反应,方便、高产率地合成了6,7-丙酮缩二醇-3-酮-庚酸乙酯(1).试图通过对甲苯磺酸-2,3-丙酮缩甘油酯(2)和乙酰乙酸乙酯双阴离子反应制备6,7-丙酮缩二醇-3-酮-庚酸乙酯(1)未获成功.所合成的化合物经元素分析,IR,1HNMR,13CNMR和MS光谱表征. The β-ketoester derivative 1 was prepared by the reaction of 2,3-propanediolglycinate (2) with ethyl acetoacetate and diethyl carbonate. A solution of (±) -1,2-propanone Glycerol as a starting material, p-toluene sulfonylation, nucleophilic substitution, decarboxylation and other reactions, to facilitate the synthesis of 6,7-acetonline-3-keto-heptanoate (1) with high yield. Attempts to prepare ethyl 6,7-acetonol-3-one-heptanoate (1) by dianion reaction of 2,3-propanediolglyceryl tosylate (2) and ethyl acetoacetate were unsuccessful The synthesized compounds were characterized by elemental analysis, IR, 1HNMR, 13CNMR and MS spectra.