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目的:探讨ALOX5基因多态性与呼吸道合胞病毒(RSV)毛细支气管炎的发生及病情严重程度的关系。方法:采用DNA测序方法检测60例RSV毛细支气管炎组(轻度组和中重度组各30例)、50例RSV无喘息组以及30例对照组婴幼儿ALOX5启动子处Spl-Egrl等位基因型基因序列。结果:4组患儿ALOX5基因启动子区变异位点基因型变异比较无统计学意义,P值均>0.05。结论:珠海地区汉族婴幼儿ALOX5启动子处的Spl-Egrl存在基因多态性,但与RSV毛细支气管炎易感性及病情严重程度无相关。
Objective: To investigate the relationship between ALOX5 gene polymorphism and the occurrence of respiratory syncytial virus (RSV) bronchiolitis and the severity of the disease. Methods: The Spl-Egr1 allele was detected by DNA sequencing in 60 cases of RSV bronchiolitis group (30 cases in mild group and moderate-severe group), 50 cases in RSV without asthma group and 30 cases in control group Type gene sequence. Results: There was no significant difference in the genotypes of ALOX5 promoter among the four groups (P> 0.05). CONCLUSIONS: Spl-Egrl at the ALOX5 promoter in Han infants in Zhuhai shows polymorphism but no association with the susceptibility to RSV bronchiolitis and the severity of the disease.