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目的评价手足口病(HFMD)患儿急性期和愈后的血清EV71型中和抗体变化。方法对安徽阜阳2008年4～8月因HFMD住院的患儿采集急性期和愈后1年血样,采用微量细胞病变中和试验方法检测EV71型中和抗体滴度。结果共调查到急性期组患儿83人和愈后1年组患儿57人。对这些病例的血清中和试验研究发现:急性期组和愈后组中和抗体阳性率差异分别为96.4%和82.5%,差异具有统计学意义(χ2=7.784,P<0.05)。急性期组和愈后组抗-EV71中和抗体GMT值分别为388.3和540.0,差异无统计学意义(t=0.907,P>0.05)。结论患儿愈后可以产生较高的抗-EV71中和抗体,且抗体可持续至少1年。
Objective To evaluate the changes of serum EV71 neutralizing antibody in children with HFMD at acute stage and post-prognosis. Methods The blood samples of acute phase and one year after the HFMD hospitalization were collected from April to August in 2008 in Fuyang, Anhui Province. The neutralization antibody titer of EV71 was detected by the method of neutralization test of microcytopathy. Results A total of 83 children in the acute phase and 57 children in the 1-year-old group were investigated. The serum neutralization test in these cases showed that the positive rates of neutralizing antibodies in acute phase group and healing group were 96.4% and 82.5%, respectively, with statistical significance (χ2 = 7.784, P <0.05). The GMT of anti-EV71 neutralizing antibody in the acute phase group and the healing group were 388.3 and 540.0 respectively, with no significant difference (t = 0.907, P> 0.05). Conclusion The more children can produce higher anti-EV71 neutralizing antibody, and the antibody can last for at least 1 year.