目的综合评价亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与食管癌易感性的关系。方法检索中国知网、万方、维普、MEDLINE、EMBASE等数据库,收集有关MTHFR基因多态性与食管癌易感性关系的文献,剔除不符合要求文献,然后用Stata 11.0软件进行分析,计算合计OR值及95%CI,并评估发表偏倚。结果共有11项病例对照研究纳入分析,与野生纯合基因型(CC)相比,杂合基因型(CT)[OR(95%CI)=1.43(1.06~1.93)]和突变纯合基因型(TT)[OR(95%CI)=1.68(1.16~2.45)]均增加食管癌的发病风险;分层分析结果显示,TT基因型与食管鳞癌的关联更为密切[TT VS CC:OR(95%CI)=1.950(1.331~2.856)]。结论 MTHFR C677T基因多态性与食管癌易感性有关,携带CT和TT基因型个体发生食管癌的风险增高。 Objective To comprehensively evaluate the relationship between MTHFR C677T polymorphism and susceptibility to esophageal cancer. Methods The databases of CNKI, Wanfang, Weipu, MEDLINE and EMBASE were searched to collect the literatures on the relationship between MTHFR gene polymorphisms and the susceptibility to esophageal cancer. The non-conforming documents were excluded and then analyzed by Stata 11.0 software. Value and 95% CI, and evaluate publication bias. Results A total of 11 case-control studies were included in the analysis, compared with wild-type genotypes (CC), heterozygous genotypes (CT) [OR (95% CI) = 1.43 (1.06 to 1.93)] and homozygous genotypes. (TT)[OR(95%CI)=1.68(1.16~2.45)] increased the risk of esophageal cancer; stratified analysis showed that the TT genotype was more closely related to esophageal squamous cell carcinoma[TT VS CC:OR (95% CI) = 1.950 (1.331 to 2.856)]. Conclusion The MTHFR C677T polymorphism is associated with the susceptibility of esophageal cancer. The individuals with CT and TT genotypes have an increased risk of developing esophageal cancer.